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Mini-brains have been fused to resemble that of a 40-day-old fetus

By fusing different human organoids, researchers have created “mini-brains” containing most of the cell types found in fetal brains

By Michael Le Page

21 February 2025

Human embryonic stem cell-derived brain organoids grown on an organ-on-chip system

Brain organoids derived from human embryonic stem cells being grown in the lab

ARTHUR CHIEN/SCIENCE PHOTO LIBRARY

Human “mini-brains” that contain 80 per cent of the cell types in a 40-day-old fetal brain have been created by fusing different organoids together.

“We’re getting to the point that we are getting closer to the fetal brain,” says Annie Kathuria at Johns Hopkins University in Maryland. The reason for doing this is to create organoids that are better suited for studying conditions such as autism and schizophrenia, which is hard to do in animals, she says.

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