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Mind

Electrical synapses genetically engineered in mammals for first time

Scientists have used gene editing to produce artificial electrical synapses in mice, where they can be targeted to make the animals more sociable or reduce their risk of OCD-like symptoms

By Chris Simms

14 April 2025

A light micrograph of a section of a whole mouse brain, with nerve cells colourfully labelled

A light micrograph of a section of a whole mouse brain, with nerve cells colourfully labelled

ARTHUR CHIEN/SCIENCE PHOTO LIBRARY

Electrical synapses that carry messages through the brain have been artificially engineered in mammals for the first time, altering their behaviour. This could have potential for preventing or treating a range of mental health conditions, including obsessive compulsive disorder (OCD).

Connections, or synapses, between nerve cells are either electrical or chemical. Chemical ones, which are more common in mammals, involve molecules called neurotransmitters, whereas electrical synapses rely on proteins called connexins.

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