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Humans

Humans evolved to survive mild burns at the expense of severe ones

Early humans had almost no hope of surviving severe burns, so evolution may have prioritised the selection of genes that heal mild ones, which could be affecting modern medicine

By Christa Lesté-Lasserre

28 April 2025

Hominins have been using fire for various reasons for at least 1 million years

SHEILA TERRY/SCIENCE PHOTO LIBRARY

Mastering fire may have also led to genetic changes that helped early humans survive mild burn injuries, but this evolutionary trait could complicate the treatment of more severe cases today.

An early-stage study suggests that the selection of genes preventing deadly infections that could arise from minor burns were prioritised in early Homo sapiens, but these same genes interfere with the healing of severe ones. This may be because, in primitive times, people with severe burns had almost no hope of surviving.…

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